首页 | 综合通知 | 教务教学 | 学术交流 | 留学信息 | 科研管理 | 文献服务 | 招标信息 | 网络服务 
当前位置: 校园公告>>学术交流>>正文
【学术报告】澳大利亚昆士兰大学Zhi Ping XU教授学术报告会通知
2019-07-13 15:03   柔性电子研究院 审核人:   (点击: )

报告题目:Tailoring clay nanoparticles for applications in biomedicine and agriculture

报告人:Zhi Ping (Gordon) XU教授

报告时间:2019年7月15日(星期一)上午10:00-11:00

报告地点:长安校区启翔楼233会议室

邀请人:李鹏教授

报告简介:

I will first introduce one typical inorganic nanoparticle, i.e. layered double hydroxide (LDH), and then demonstrate its high potential as the drug/gene delivery platform, including easy preparation, high loading capacity, quick endosome escape and low cytotoxicity. I will then present how to maintain the colloidal stability and avoid the aggregation in medium and blood for in vivo application.

One potential application of clay nanoparticles is vaccine adjuvants that promote higher and long-term immune responses against cancer and bacteria. We have found that LDH is able to readily load model antigen ovalbumin (OVA) and the toll-like receptor ligand CpG together, promote higher levels of specific antibodies, and modulate the immune response from Th2 bias towards the preferred polarity Th1 for anti-cancer purpose, as further evidenced with co-delivery of three antigens for effective inhibition of tumor growth.

The second potential application is acting as an excellent MRI contrast agent for tumor imaging and diagnosis. As LDH is a weak base, the Mn-doped LDH nanoparticles show an pH-ultra-sensitive relaxivity, with the r1 relaxivity being 9-10 mM-1 s-1, and clearly image the tumor tissue. LDH nanoparticles can also be made as multifunctional nanomedicine, combining two therapeutic modules for synergistic treatment of cancers. I will present a few examples to demonstrate the combination therapy for efficient inhibition of tumor growth in mouse model.

A very possible application is used as a carrier for double stranded RNA topical delivery to protect the plants against virus, as will be presented with our current research. This is a good example combining the plant biotechnology and nanotechnology for crop protection, taking the advantage of LDH nanomaterials’ particular property in the field of nano-agro-technology.

报告人简介:



Professor Zhi Ping Xu is a senior group leader at the Australian Institute for Bioengineering and Nanotechnology. His research focuses on control preparation of LDH nanomaterials, calcium phosphate nanoparticles, nanoemulsions, quantum dots, chemosensros and nanosensors, and their applications in biomedicine and agriculture. He has published over 250 journal papers with the total citations > 10,500 times and H index of 55. He has been awarded over $15 million grants for his research.

Professor Zhi Ping (Gordon) Xu is an Australian Research Council (ARC) Future Fellow (2013-2016) and UQ VC Senior Research Fellow (2017-2019). Since 2004, He has received a number of fellowships and awards, including an ARC Australian Postdoctoral Fellowship (2005-2007), ARC Australian Research Fellowship (2008-2012), and UQ Foundation’s Research Excellence Award (2009). Professor Xu is an ARC and NHMRC referee, and a board member of 6 international journals.

关闭窗口
最新公告
西北工业大学第六届翱翔青年学者论坛...
关于在西北工业大学举办企业高级管理...
材料分析创新中心仪器设备操作暑期培...
关于2019年“暑期国际学堂”的通知
我的人生我做主——西工大学生处王莉...
关于举办庆祝新中国成立70周年——用...
西北工业大学庆祝中华人民共和国成立7...
关于西北工业大学2019年“运筹帷幄,...
2018-2019CUVA中国大学生排球联赛总决...
关于转发《第八届西北联大与中国高等...
西工大主页  招聘信息  就业信息  本科招生  研招信息
版权所有©西北工业大学  地址:西安市友谊西路127号 邮编:710072